MITOCHONDRIAL REPLACEMENT IN THE ENGLISH-LANGUAGE PRINT MEDIA: CONTINUITY AND CHANGE IN METAPHORS AND SOCIAL REPRESENTATIONS

Mitochondrial replacement in the English-language print media: continuity and change in metaphors and social representations

In May 2023, The Guardian announced that babies had been born through mitochondrial replacement therapy (MRT).MRT and its ethical and legal implications have been discussed in the media for over a decade.These discussions have been examined by social scientists and communication scholars.In this article, we seek to determine whether and, if so, how

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Succinate dehydrogenase deficiency-driven succinate accumulation induces drug resistance in acute myeloid leukemia via ubiquitin-cullin regulation

Abstract Drug resistance is vital for the poor prognosis of acute myeloid leukemia (AML) patients, but the underlying mechanism remains poorly understood.Given the unique microenvironment of bone marrow, we reasoned that drug resistance of AML might rely on distinct metabolic processes.Here, we identify succinate dehydrogenase (SDH) deficiency and

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